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(1)H and (13)C-NMR and Molecular Dynamics Studies of Cyclosporin A Interacting with Magnesium(II) or Cerium(III) in Acetonitrile. Conformational Changes and cis-trans Conversion of Peptide Bonds

Cyclosporin A (CsA) is an important drug used to prevent graft rejection in organ transplantations. Its immunosuppressive activity is related to the inhibition of T-cell activation through binding with the proteins Cyclophilin (Cyp) and, subsequently, Calcineurin (CN). In the complex with its target...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Bernardi, Francesca, Gaggelli, Elena, Molteni, Elena, Porciatti, Elena, Valensin, Daniela, Valensin, Gianni
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Biophysical Society 2006
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367286/
https://ncbi.nlm.nih.gov/pubmed/16299069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.074245
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