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Essential Role for Protein Kinase D Family Kinases in the Regulation of Class II Histone Deacetylases in B Lymphocytes

We have taken a knockout approach to interrogate the function of protein kinase D (PKD) serine/threonine kinases in lymphocytes. DT40 B cells express two PKD family members, PKD1 and PKD3, which are both rapidly activated by the B-cell antigen receptor (BCR). DT40 cells with single or dual deletions...

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Autors principals: Matthews, Sharon A., Liu, Ping, Spitaler, Martin, Olson, Eric N., McKinsey, Timothy A., Cantrell, Doreen A., Scharenberg, Andrew M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367196/
https://ncbi.nlm.nih.gov/pubmed/16449666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1569-1577.2006
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