The Hepatitis C Virus RNA-Dependent RNA Polymerase Membrane Insertion Sequence Is a Transmembrane Segment

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) belongs to a class of membrane proteins termed tail-anchored proteins. Here, we show that the HCV RdRp C-terminal membrane insertion sequence traverses the phospholipid bilayer as a transmembrane segment. Moreover, the HCV RdRp was foun...

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Autores principales: Ivashkina, Natalia, Wölk, Benno, Lohmann, Volker, Bartenschlager, Ralf, Blum, Hubert E., Penin, François, Moradpour, Darius
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC136709/
https://ncbi.nlm.nih.gov/pubmed/12438637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.24.13088-13093.2002
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