Aspergillus fumigatus C-5 Sterol Desaturases Erg3A and Erg3B: Role in Sterol Biosynthesis and Antifungal Drug Susceptibility

Two erg3 genes encoding C-5 sterol desaturase enzymes (Erg3A and Erg3B) in Aspergillus fumigatus were characterized with respect to their nucleotide sequences and null mutant phenotypes. Targeted disruption of the erg3A and erg3B genes and a double gene knockout, erg3A(−) erg3B(−), showed that they...

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Autori principali: Alcazar-Fuoli, Laura, Mellado, Emilia, Garcia-Effron, Guillermo, Buitrago, Maria J., Lopez, Jordi F., Grimalt, Joan O., Cuenca-Estrella, J. Manuel, Rodriguez-Tudela, Juan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366924/
https://ncbi.nlm.nih.gov/pubmed/16436696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.453-460.2006
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