Human Immunoglobulin G Recognizing Fibrinogen-Binding Surface Proteins Is Protective against both Staphylococcus aureus and Staphylococcus epidermidis Infections In Vivo

A human donor-selected immunoglobulin G for intravenous injection (IGIV) product with elevated titers against the staphylococcal fibrinogen-binding MSCRAMM proteins ClfA and SdrG (INH-A21) was tested in vitro and in vivo. INH-A21 contained a significantly increased ability to inhibit the fibrinogen-...

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Autors principals: Vernachio, John H., Bayer, Arnold S., Ames, Brenda, Bryant, Dawn, Prater, Bradley D., Syribeys, Peter J., Gorovits, Elena L., Patti, Joseph M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366878/
https://ncbi.nlm.nih.gov/pubmed/16436704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.511-518.2006
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