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Initial Conformational Changes of Human Transthyretin under Partially Denaturing Conditions
Human transthyretin (TTR) is an amyloidogenic protein. The pathway of TTR amyloid formation has been proposed based on lines of evidence: TTR tetramer first dissociates into native monomers, which is shown to be a rate-limiting step in the formation of fibrils. Subsequently, the monomeric species pa...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Biophysical Society
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1366544/ https://ncbi.nlm.nih.gov/pubmed/15821170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.059642 |
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