Inhibition of PACT-Mediated Activation of PKR by the Herpes Simplex Virus Type 1 Us11 Protein
PACT, a protein activator of PKR, can cause inhibition of cellular protein synthesis and apoptosis. Here, we report that the Us11 protein of herpes simplex virus type 1 can block PKR activation by PACT both in vitro and in vivo. Although Us11 can bind to both PKR and PACT, mutational analyses reveal...
Αποθηκεύτηκε σε:
| Εκδόθηκε σε: | J Virol |
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| Κύριοι συγγραφείς: | , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Microbiology (ASM)
2002
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136652/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12368348/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.21.11054-11064.2002 |
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