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The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides.

The effects of the CYP2C19 substrates, mephenytoin, methsuximide and mephobarbitone on the metabolism of proguanil and chlorproguanil by human liver microsomes were studied. All of the CYP2C19 substrates significantly inhibited (P < 0.05) the formation of both cycloguanil and chlorcycloguanil fro...

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Detaylı Bibliyografya
Asıl Yazarlar: Wright, J D, Helsby, N A, Ward, S A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1995
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1365133/
https://ncbi.nlm.nih.gov/pubmed/7640152
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