Cytochrome P4502D6 genotype does not determine response to clozapine.

1. The atypical antipsychotic drug clozapine, used in the treatment of resistant schizophrenia, is metabolized partly by the hepatic cytochrome P450 enzyme CYP2D6. Two phenotypes with respect to the activity of the enzyme are recognized (extensive metabolisers (EM) and poor metabolisers (PM)), resul...

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Detalhes bibliográficos
Main Authors: Arranz, M J, Dawson, E, Shaikh, S, Sham, P, Sharma, T, Aitchison, K, Crocq, M A, Gill, M, Kerwin, R, Collier, D A
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1365130/
https://ncbi.nlm.nih.gov/pubmed/7640149
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