Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy.

The aim of the present study was to investigate the role of poly (ADP-ribose) synthetase in acute local inflammation (carrageenan-induced pleurisy), where oxyradicals, nitric oxide and peroxynitrite are known to play a crucial role in the inflammatory process. DNA single-strand breakage and activati...

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Bibliografische gegevens
Hoofdauteurs: Cuzzocrea, S, Caputi, A P, Zingarelli, B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1998
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364111/
https://ncbi.nlm.nih.gov/pubmed/9536124
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