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Cleavage of Influenza A Virus Hemagglutinin in Human Respiratory Epithelium Is Cell Associated and Sensitive to Exogenous Antiproteases

Proteolytic cleavage of the hemagglutinin (HA) of human influenza viruses A/Aichi/2/68 (H3N2) and A/WSN/34 (H1N1) from HA0 to HA1/HA2 was studied in primary human adenoid epithelial cells (HAEC). HAEC contain a mixture of ciliated and nonciliated secretory cells and mimic the epithelium membrane of...

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Detalhes bibliográficos
Main Authors: Zhirnov, Oleg P., Ikizler, Mine R., Wright, Peter F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136409/
https://ncbi.nlm.nih.gov/pubmed/12163588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.17.8682-8689.2002
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