Viral RNA Mutations Are Region Specific and Increased by Ribavirin in a Full-Length Hepatitis C Virus Replication System

High rates of genetic variation ensure the survival of RNA viruses. Although this variation is thought to result from error-prone replication, RNA viruses must also maintain highly conserved genomic segments. A balance between conserved and variable viral elements is especially important in order fo...

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Main Authors: Contreras, Ana Maria, Hiasa, Yoichi, He, Wenping, Terella, Adam, Schmidt, Emmett V., Chung, Raymond T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136407/
https://ncbi.nlm.nih.gov/pubmed/12163570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.17.8505-8517.2002
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