Half-Life of the Duck Hepatitis B Virus Covalently Closed Circular DNA Pool In Vivo following Inhibition of Viral Replication

Covalently closed circular DNA (cccDNA) is a crucial intermediate in the replication of hepadnaviruses. We inhibited the replication of duck hepatitis B virus in congenitally infected ducks with a combination of lamivudine and a dideoxyguanosine prodrug. Inhibition of viral replication should preven...

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Pubblicato in:	J Virol
Autori principali:	Addison, William R., Walters, Kathie-Anne, Wong, Winnie W. S., Wilson, John S., Madej, Danuta, Jewell, Lawrence D., Tyrrell, D. Lorne J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136192/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12021368/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.12.6356-6363.2002
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