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p16(INK4a) Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells
Aneuploidy, frequently observed in premalignant lesions, disrupts gene dosage and contributes to neoplastic progression. Theodor Boveri hypothesized nearly 100 years ago that aneuploidy was due to an increase in centrosome number (multipolar mitoses) and the resultant abnormal segregation of chromos...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1361797/ https://ncbi.nlm.nih.gov/pubmed/16464125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040051 |
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