Blocking the α4 integrinαpaxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site

Antagonists to α4 integrin show promise for several autoimmune and inflammatory diseases but may exhibit mechanism-based toxicities. We tested the capacity of blockade of α4 integrin signaling to perturb functions involved in inflammation, while limiting potential adverse effects. We generated and c...

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Hauptverfasser: Féral, Chloé C., Rose, David M., Han, Jaewon, Fox, Norma, Silverman, Gregg J., Kaushansky, Kenneth, Ginsberg, Mark H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1361348/
https://ncbi.nlm.nih.gov/pubmed/16470243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26091
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