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Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15

The goal of this study was to elucidate the molecular mechanism by which type I IFN inhibits assembly and release of HIV-1 virions. Our study revealed that the IFN-induced ubiquitin-like protein ISG15 mimics the IFN effect and inhibits release of HIV-1 virions without having any effect on the synthe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Okumura, Atsushi, Lu, Gengshi, Pitha-Rowe, Ian, Pitha, Paula M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360585/
https://ncbi.nlm.nih.gov/pubmed/16434471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510518103
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