Naturally Elicited Antibodies to Glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum Require Intact GPI Structures for Binding and Are Directed Primarily against the Conserved Glycan Moiety

Immunization with a synthetic glycan corresponding to Plasmodium falciparum glycosylphosphatidylinositols (GPIs) has been proposed as a vaccination strategy against malaria. We investigated the structural requirements for binding of naturally elicited anti-GPI antibodies to parasite GPIs. The data s...

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Auteurs principaux: Naik, Ramachandra S., Krishnegowda, Gowdahalli, Ockenhouse, Christian F., Gowda, D. Channe
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
Sujets:
Fungal and Parasitic Infections
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360366/
https://ncbi.nlm.nih.gov/pubmed/16428795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.2.1412-1415.2006
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