Toll-Like Receptor 4 Protects against Lethal Leptospira interrogans Serovar Icterohaemorrhagiae Infection and Contributes to In Vivo Control of Leptospiral Burden

The roles of innate immune responses in protection from or pathogenesis of severe leptospirosis remain unclear. We examined the role of Toll-like receptors (TLRs) in mouse infection and macrophage responses to Leptospira. C3H/HeJ mice (TLR4 deficient) and C3H/HeJ-SCID mice, but not C3H/OuJ mice (TLR...

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Detalhes bibliográficos
Main Authors: Viriyakosol, Suganya, Matthias, Michael A., Swancutt, Mark A., Kirkland, Theo N., Vinetz, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360355/
https://ncbi.nlm.nih.gov/pubmed/16428731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.2.887-895.2006
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