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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

We report here the results of a systematic high-resolution X-ray crystallographic analysis of complexes of the hepatitis C virus (HCV) RNA polymerase with ribonucleoside triphosphates (rNTPs) and divalent metal ions. An unexpected observation revealed by this study is the existence of a specific rGT...

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Udgivet i:J Virol
Principais autores: Bressanelli, Stéphane, Tomei, Licia, Rey, Félix A., De Francesco, Raffaele
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136026/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884572/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.7.3482-3492.2002
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