Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment

Impairment of hippocampal function precedes frontal and parietal cortex impairment in human Alzheimer's disease (AD). Neurotrophins are critical for behavioral performance and neuronal survival in AD. We used complex and radial mazes to assess spatial orientation and learning in wild-type and B...

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Autori principali: Hellweg, Rainer, Lohmann, Peter, Huber, Roman, Kühl, Alexander, Riepe, Matthias W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2006
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360134/
https://ncbi.nlm.nih.gov/pubmed/16418433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.2606
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