Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals

Epithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic disease, but the basis for the altered epithelial phenotype is often uncertain. Here we show that long-term ciliated cell hyperplasia coincides with mucous (goblet) cell metaplasia after respiratory viral cleara...

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Autori principali: Tyner, Jeffrey W., Kim, Edy Y., Ide, Kyotaro, Pelletier, Mark R., Roswit, William T., Morton, Jeffrey D., Battaile, John T., Patel, Anand C., Patterson, G. Alexander, Castro, Mario, Spoor, Melanie S., You, Yingjian, Brody, Steven L., Holtzman, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1359039/
https://ncbi.nlm.nih.gov/pubmed/16453019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25167
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