Human CD59 Incorporation into Porcine Endogenous Retrovirus Particles: Implications for the Use of Transgenic Pigs for Xenotransplantation

Transgenic pigs have been engineered to express human CD59 (hCD59) in order to suppress hyperacute rejection of xenotransplants in human recipients. In this study, porcine endogenous retrovirus (PERV) was produced in a porcine cell line expressing hCD59 in order to examine the effect of this complem...

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Detalhes bibliográficos
Main Authors: Takefman, Daniel M., Spear, Gregory T., Saifuddin, Mohammed, Wilson, Carolyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135898/
https://ncbi.nlm.nih.gov/pubmed/11799196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1999-2002.2002
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