The Herpes Simplex Virus Type 2 R1 Protein Kinase (ICP10 PK) Blocks Apoptosis in Hippocampal Neurons, Involving Activation of the MEK/MAPK Survival Pathway

Herpes simplex virus type 1 (HSV-1) and HSV-2 trigger or counteract apoptosis by a cell-specific mechanism. Our studies are based on previous findings that the protein kinase (PK) domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) activates the Ras/MEK/MAPK pathway (Smith et al.,...

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Detalhes bibliográficos
Main Authors: Perkins, D., Pereira, E. F. R., Gober, M., Yarowsky, P. J., Aurelian, L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135835/
https://ncbi.nlm.nih.gov/pubmed/11773417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.3.1435-1449.2002
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