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Molecular Dissection of the Semliki Forest Virus Homotrimer Reveals Two Functionally Distinct Regions of the Fusion Protein

Semliki Forest virus (SFV) is an enveloped alphavirus that infects cells via a membrane fusion reaction triggered by the acidic pH of endosomes. In response to low pH, the E1 proteins on the virus membrane undergo a series of conformational changes, resulting in the formation of a stable E1 homotrim...

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Detalhes bibliográficos
Main Authors: Gibbons, Don L., Kielian, Margaret
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135824/
https://ncbi.nlm.nih.gov/pubmed/11773395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.3.1194-1205.2002
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