Mutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases

Colicin E9 is a microbial toxin that kills bacteria through random degradation of chromosomal DNA. Within the active site of the cytotoxic endonuclease domain of colicin E9 (the E9 DNase) is a 32 amino acid motif found in the H-N-H group of homing endonucleases. Crystal structures of the E9 DNase ha...

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Bibliographic Details
Main Authors: Walker, David C., Georgiou, Theonie, Pommer, Ansgar J., Walker, Daniel, Moore, Geoffrey R., Kleanthous, Colin, James, Richard
Format: Artigo
Language:Inglês
Published: Oxford University Press 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC135741/
https://ncbi.nlm.nih.gov/pubmed/12136104
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