Increased Efficacy of the Immunoglobulin G2a Subclass in Antibody-Mediated Protection against Lactate Dehydrogenase-Elevating Virus-Induced Polioencephalomyelitis Revealed with Switch Mutants

Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyel...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Markine-Goriaynoff, Dominique, Coutelier, Jean-Paul
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2002
Pynciau:
Pathogenesis and Immunity
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC135718/
https://ncbi.nlm.nih.gov/pubmed/11739710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.1.432-435.2002
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