Increased Efficacy of the Immunoglobulin G2a Subclass in Antibody-Mediated Protection against Lactate Dehydrogenase-Elevating Virus-Induced Polioencephalomyelitis Revealed with Switch Mutants

Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyel...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Markine-Goriaynoff, Dominique, Coutelier, Jean-Paul
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Pathogenesis and Immunity
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135718/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.1.432-435.2002
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