Tumor-Associated Down-Regulation of 15-Lipoxygenase-1 Is Reversed by Celecoxib in Colorectal Cancer

OBJECTIVE: To evaluate the role of celecoxib on 15-lipoxygenase-1 (15-LOX-1) expression, protein levels, and rates of apoptosis in colorectal cancer cell lines. Also, to evaluate the expression of 15-LOX-1 in human normal mucosa, adenoma, and carcinoma with correlation to overall survival. SUMMARY B...

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Hauptverfasser: Heslin, Martin J., Hawkins, Ashley, Boedefeld, William, Arnoletti, J Pablo, Frolov, Andrey, Soong, Richie, Urist, Marshall M., Bland, Kirby I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1357173/
https://ncbi.nlm.nih.gov/pubmed/15912043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.sla.0000164177.95620.c1
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