Vaccine-Induced Immune Responses in Rodents and Nonhuman Primates by Use of a Humanized Human Immunodeficiency Virus Type 1 pol Gene

A synthetic gene consisting of the reverse transcriptase (RT) and integrase (IN) domains of human immunodeficiency virus type 1 (HIV-1) pol was constructed using codons most frequently used in humans. The humanized pol gave dramatically improved levels of Rev-independent, in vitro protein production...

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Detalhes bibliográficos
Main Authors: Casimiro, Danilo R., Tang, Aimin, Perry, Helen C., Long, Romnie S., Chen, Minchun, Heidecker, Gwendolyn J., Davies, Mary-Ellen, Freed, Daniel C., Persaud, Natasha V., Dubey, Sheri, Smith, Jeffrey G., Havlir, Diane, Richman, Douglas, Chastain, Michael A., Simon, Adam J., Fu, Tong-Ming, Emini, Emilio A., Shiver, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135696/
https://ncbi.nlm.nih.gov/pubmed/11739684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.1.185-194.2002
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