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Deletion of the Tetrahymena thermophila rDNA replication fork barrier region disrupts macronuclear rDNA excision and creates a fragile site in the micronuclear genome
During macronuclear development the Tetrahymena thermophila ribosomal RNA gene is excised from micronuclear chromosome 1 by site-specific cleavage at chromosome breakage sequence (Cbs) elements, rearranged into a ‘palindromic’ 21 kb minichromosome and extensively amplified. Gene amplification initia...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2006
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356531/ https://ncbi.nlm.nih.gov/pubmed/16449202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj466 |
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