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Transformation of Bone Marrow B-Cell Progenitors by E2A-HLF Requires Coexpression of BCL-2

The chimeric transcription factor E2a-Hlf is an oncoprotein associated with a subset of acute lymphoblastic leukemias of early B-lineage derivation. We employed a retroviral transduction-transplantation approach to evaluate the oncogenic effects of E2a-Hlf on murine B-cell progenitors harvested from...

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Detalhes bibliográficos
Main Authors: Smith, Kevin S., Rhee, Joon Whan, Cleary, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135651/
https://ncbi.nlm.nih.gov/pubmed/12370314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7678-7687.2002
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