Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

Using a novel tissue-specific RNA interference (RNAi) approach that mimics the principle by which naturally occurring microRNAs (miRNA) are made, we demonstrate that the Wilms' tumor 1 (WT1) transcription factor has an essential role in spermatogenesis. Mice depleted of WT1 in Sertoli nurse cel...

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Bibliographische Detailangaben
Hauptverfasser: Rao, Manjeet K., Pham, John, Imam, J. Saadi, MacLean, James A., Murali, Deepa, Furuta, Yasuhide, Sinha-Hikim, Amiya P., Wilkinson, Miles F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2006
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356106/
https://ncbi.nlm.nih.gov/pubmed/16418481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad1367806
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