Mutants of Streptomyces clavuligerus with Disruptions in Different Genes for Clavulanic Acid Biosynthesis Produce Large Amounts of Holomycin: Possible Cross-Regulation of Two Unrelated Secondary Metabolic Pathways

A Streptomyces clavuligerus ccaR::aph strain, which has a disruption in the regulatory gene ccaR, does not produce cephamycin C or clavulanic acid, but does produce a bioactive compound that was identified as holomycin by high-performance liquid chromatography (HPLC) and infrared and mass spectromet...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: de la Fuente, Alvaro, Lorenzana, Luis M., Martín, Juan F., Liras, Paloma
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Physiology and Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC135446/
https://ncbi.nlm.nih.gov/pubmed/12426344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.23.6559-6565.2002
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge