Substrate Specificity of the RND-Type Multidrug Efflux Pumps AcrB and AcrD of Escherichia coli Is Determined Predominately by Two Large Periplasmic Loops

AcrAB-TolC is a constitutively expressed, tripartite efflux transporter complex that functions as the primary resistance mechanism to lipophilic drugs, dyes, detergents, and bile acids in Escherichia coli. TolC is an outer membrane channel, and AcrA is an elongated lipoprotein that is hypothesized t...

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Pubblicato in:	J Bacteriol
Autori principali:	Elkins, Christopher A., Nikaido, Hiroshi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Physiology and Metabolism
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12426336/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.184.23.6490-6498.2002
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