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Amplification of the Tetracycline Resistance Determinant of pAMα1 in Enterococcus faecalis Requires a Site-Specific Recombination Event Involving Relaxase

The small multicopy plasmid pAMα1 (9.75 kb) encoding tetracycline resistance in Enterococcus faecalis is known to generate tandem repeats of a 4.1-kb segment carrying tet(L) when cells are grown extensively in the presence of tetracycline. Here we show that the initial (rate-limiting) step involves...

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Autores principales: Francia, M. Victoria, Clewell, Don B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC135321/
https://ncbi.nlm.nih.gov/pubmed/12193637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.18.5187-5193.2002
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