Tet(L) and Tet(K) Tetracycline-Divalent Metal/H(+) Antiporters: Characterization of Multiple Catalytic Modes and a Mutagenesis Approach to Differences in Their Efflux Substrate and Coupling Ion Preferences

The Tet(L) protein encoded in the Bacillus subtilis chromosome and the closely related Tet(K) protein from Staphylococcus aureus plasmids are multifunctional antiporters that have three cytoplasmic efflux substrates: a tetracycline-divalent metal (TC-Me(2+)) complex that bears a net single positive...

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Pubblicato in:	J Bacteriol
Autori principali:	Jin, Jie, Guffanti, Arthur A., Bechhofer, David H., Krulwich, Terry A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Physiology and Metabolism
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135290/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12169596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.184.17.4722-4732.2002
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