Mutations in the CCGTTCACA DnaA Box of Mycobacterium tuberculosis oriC That Abolish Replication of oriC Plasmids Are Tolerated on the Chromosome

The origin of replication (oriC) region in some clinical strains of Mycobacterium tuberculosis is a hot spot for IS6110 elements. To understand how clinical strains with insertions in oriC can replicate their DNA, we characterized the oriC regions of some clinical strains. Using a plasmid-based oriC...

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Bibliographic Details
Main Authors: Dziadek, Jaroslaw, Rajagopalan, Malini, Parish, Tanya, Kurepina, Natalia, Greendyke, Rebecca, Kreiswirth, Barry N., Madiraju, Murty V. V. S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Molecular Biology of Pathogens
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC135179/
https://ncbi.nlm.nih.gov/pubmed/12081955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.14.3848-3855.2002
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