Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

Inflammatory diseases of the CNS, such as MS and its animal model EAE, are characterized by infiltration of activated lymphocytes and phagocytes into the CNS. Within the CNS, activation of resident cells initiates an inflammatory cascade, leading to tissue destruction, demyelination, and neurologic...

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Bibliographic Details
Main Authors: Prinz, Marco, Garbe, Folker, Schmidt, Hauke, Mildner, Alexander, Gutcher, Ilona, Wolter, Karina, Piesche, Matthias, Schroers, Roland, Weiss, Elisabeth, Kirschning, Carsten J., Rochford, Christian D.P., Brück, Wolfgang, Becher, Burkhard
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2006
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1350999/
https://ncbi.nlm.nih.gov/pubmed/16440059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26078
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