Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) patients and are refractory to phagocytosis and antibiotics. Here we show that mucoid bacteria perish during anaerobic exposure to 15 mM nitrite (NO(2)(–)) at pH 6.5, which mimics CF airway mucus. Killin...

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Detalhes bibliográficos
Main Authors: Yoon, Sang Sun, Coakley, Ray, Lau, Gee W., Lymar, Sergei V., Gaston, Benjamin, Karabulut, Ahmet C., Hennigan, Robert F., Hwang, Sung-Hei, Buettner, Garry, Schurr, Michael J., Mortensen, Joel E., Burns, Jane L., Speert, David, Boucher, Richard C., Hassett, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1350997/
https://ncbi.nlm.nih.gov/pubmed/16440061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24684
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