Escherichia coli DNA Polymerase III Can Replicate Efficiently past a T-T cis-syn Cyclobutane Dimer if DNA Polymerase V and the 3′ to 5′ Exonuclease Proofreading Function Encoded by dnaQ Are Inactivated

Although very little replication past a T-T cis-syn cyclobutane dimer normally takes place in Escherichia coli in the absence of DNA polymerase V (Pol V), we previously observed as much as half of the wild-type bypass frequency in Pol V-deficient (ΔumuDC) strains if the 3′ to 5′ exonuclease proofrea...

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Main Authors: Borden, Angela, O'Grady, Paul I., Vandewiele, Dominique, Fernández de Henestrosa, Antonio R., Lawrence, Christopher W., Woodgate, Roger
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Genetics and Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC135032/
https://ncbi.nlm.nih.gov/pubmed/11976296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.10.2674-2681.2002
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