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Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase

Myotubularins, a large family of catalytically active and inactive proteins, belong to a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as physiological substrates. Here, by integrating crystallographic and deuterium-exchange mass spect...

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Detalles Bibliográficos
Main Authors: Begley, Michael J., Taylor, Gregory S., Brock, Melissa A., Ghosh, Partho, Woods, Virgil L., Dixon, Jack E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1347996/
https://ncbi.nlm.nih.gov/pubmed/16410353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510006103
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