Topologically Fixed SecG Is Fully Functional

It has been proposed that the bitopic membrane protein SecG undergoes topology inversion during translocation of (pre)proteins via SecYEG. Here we show that SecG covalently cross-linked to SecY cannot invert its topology while remaining fully functional in protein translocation. Our results strongly...

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Hlavní autoři: van der Sluis, Eli O., van der Vries, Erhard, Berrelkamp, Greetje, Nouwen, Nico, Driessen, Arnold J. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Microbial Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1347354/
https://ncbi.nlm.nih.gov/pubmed/16428426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.188.3.1188-1190.2006
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