A Gammaherpesvirus 68 Gene 50 Null Mutant Establishes Long-Term Latency in the Lung but Fails To Vaccinate against a Wild-Type Virus Challenge

The gammaherpesvirus immediate-early genes are critical regulators of virus replication and reactivation from latency. Rta, encoded by gene 50, serves as the major transactivator of the lytic program and is highly conserved among all the gammaherpesviruses, including Epstein-Barr virus, Kaposi'...

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Detalhes bibliográficos
Main Authors: Moser, Janice M., Farrell, Michael L., Krug, Laurie T., Upton, Jason W., Speck, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346930/
https://ncbi.nlm.nih.gov/pubmed/16415035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1592-1598.2006
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