Mutant Lrp1 Knock-In Mice Generated by Recombinase-Mediated Cassette Exchange Reveal Differential Importance of the NPXY Motifs in the Intracellular Domain of LRP1 for Normal Fetal Development

Lrp1 knock-in mice carrying either a wild-type allele or three different mutated alleles encoding the multifunctional endocytic receptor LRP1 were generated by recombinase-mediated cassette exchange (RMCE). Reinsertion by RMCE of a wild-type allele led to a normal pattern and level of gene expressio...

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Detalhes bibliográficos
Main Authors: Roebroek, Anton J. M., Reekmans, Sara, Lauwers, Annick, Feyaerts, Nathalie, Smeijers, Liesbet, Hartmann, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346909/
https://ncbi.nlm.nih.gov/pubmed/16382151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.2.605-616.2006
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