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Tissue Transglutaminase Serves as an Inhibitor of Apoptosis by Cross-Linking Caspase 3 in Thapsigargin-Treated Cells
Thapsigargin (THG) is an inhibitor of the endoplasmic reticulum Ca(2+)-ATPase that induces caspase 3 activation and apoptosis in HCT116 cells through a Bax-dependent pathway. In Bax-deficient HCT116 cells, however, THG specifically generates two additional species of caspase 3, termed p40 and p64, w...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1346894/ https://ncbi.nlm.nih.gov/pubmed/16382148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.2.569-579.2006 |
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