Naïve and Memory Cell Turnover as Drivers of CCR5-to-CXCR4 Tropism Switch in Human Immunodeficiency Virus Type 1: Implications for Therapy

Early human immunodeficiency virus infection is characterized by the predominance of CCR5-tropic (R5) virus. However, in many individuals CXCR4-tropic (X4) virus appears in late infection. The reasons for this phenotypic switch are unclear. The patterns of chemokine receptor expression suggest that...

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Bibliographic Details
Main Authors: Ribeiro, Ruy M., Hazenberg, Mette D., Perelson, Alan S., Davenport, Miles P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346847/
https://ncbi.nlm.nih.gov/pubmed/16378982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.2.802-809.2006
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