Multiple-Dose Pharmacokinetics and Safety of the New Antifungal Triazole BAL4815 after Intravenous Infusion and Oral Administration of Its Prodrug, BAL8557, in Healthy Volunteers

BAL8557 is the water-soluble prodrug of BAL4815, a new broad-spectrum antifungal. Healthy male subjects were randomly assigned to four treatment cohorts to receive multiple oral doses or multiple 1-h constant-rate intravenous infusions of BAL8557. Loading doses of BAL8557 were equivalent to 100 mg (...

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Main Authors: Schmitt-Hoffmann, Anne, Roos, Brigitte, Maares, Jürgen, Heep, Markus, Spickerman, Jochen, Weidekamm, Erhard, Brown, Tom, Roehrle, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
Assuntos:
Clinical Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346776/
https://ncbi.nlm.nih.gov/pubmed/16377699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.286-293.2006
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