Single-Ascending-Dose Pharmacokinetics and Safety of the Novel Broad-Spectrum Antifungal Triazole BAL4815 after Intravenous Infusions (50, 100, and 200 Milligrams) and Oral Administrations (100, 200, and 400 Milligrams) of Its Prodrug, BAL8557, in Healthy Volunteers

BAL8557 is the water-soluble prodrug of a novel antifungal triazole, BAL4815. BAL4815 is active against a broad spectrum of major opportunistic and pathogenic fungi, including strains that are resistant to other azoles. Cohorts of healthy male subjects received single-ascending oral (p.o.) doses of...

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Autores principales: Schmitt-Hoffmann, Anne, Roos, Brigitte, Heep, Markus, Schleimer, Michael, Weidekamm, Erhard, Brown, Tom, Roehrle, Michael, Beglinger, Christoph
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Clinical Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346775/
https://ncbi.nlm.nih.gov/pubmed/16377698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.279-285.2006
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