In Vivo Efficacies and Pharmacokinetics of DX-619, a Novel Des-Fluoro(6) Quinolone, against Streptococcus pneumoniae in a Mouse Lung Infection Model

DX-619 is a novel des-fluoro(6) quinolone with potent activity against gram-positive pathogens. The in vivo activity of DX-619 against Streptococcus pneumoniae was compared with those of fluoro(6) quinolones, sitafloxacin, and ciprofloxacin in a mouse model. Two strains of S. pneumoniae were used: a...

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Detalhes bibliográficos
Main Authors: Fukuda, Yuichi, Yanagihara, Katsunori, Ohno, Hideaki, Higashiyama, Yasuhito, Miyazaki, Yoshitsugu, Tsukamoto, Kazuhiro, Hirakata, Yoichi, Tomono, Kazunori, Mizuta, Yohei, Tashiro, Takayoshi, Kohno, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346772/
https://ncbi.nlm.nih.gov/pubmed/16377676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.121-125.2006
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