Inhibition of Macrophage Apoptosis by Neisseria meningitidis Requires Nitric Oxide Detoxification Mechanisms

Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric...

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Detalhes bibliográficos
Main Authors: Tunbridge, Anne J., Stevanin, Tania M., Lee, Margaret, Marriott, Helen M., Moir, James W. B., Read, Robert C., Dockrell, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346626/
https://ncbi.nlm.nih.gov/pubmed/16369030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.1.729-733.2006
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