Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence

The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10-kDa culture filtrate protein CFP-10, and is missing from the vaccine strains M. bovis BCG and M. microti. Here, we systematicall...

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Detalhes bibliográficos
Main Authors: Brodin, Priscille, Majlessi, Laleh, Marsollier, Laurent, de Jonge, Marien I., Bottai, Daria, Demangel, Caroline, Hinds, Jason, Neyrolles, Olivier, Butcher, Philip D., Leclerc, Claude, Cole, Stewart T., Brosch, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2006
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346617/
https://ncbi.nlm.nih.gov/pubmed/16368961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.1.88-98.2006
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